Dose-Response Correlation is Possible in Radioiodine Therapy of Hyperthyroidism

Radioiodine therapy of hyperthyroidism is an established treatment modality, alternative to surgery and iodine isotope I-131 has been used in nuclear medicine for several decades to treat both benign and malignant thyroid diseases. Initial studies have recognized that the effect of radiation on healthy or malignant tissue depends on the amount of radiation delivered. A dosimetric approach to iodine therapy for hyperthyroidism can allow a lower iodine dose administration and a lower manifestation of side effect like hypothyroidism. Despite that many clinicians consider dosimetry in thyroid application of dubious importance. Possibility of dose-response correlation is here discussed.

Keywords: Hyperthyroidism; radioiodine-131I; nuclear therapy; dosimetry.